Table 3.
Clinical outcomes
| All participants (n=553) | ||
|---|---|---|
| Ventilatory support | ||
| Ventilator-free days at day 28 | 0·0 (0·0–15·0) | |
| Mean (SD) | 6·8 (8·5) | |
| Successful extubation | 266/553 (48%) | |
| Duration of ventilation, days | 13·5 (7·5–22·5) | |
| In survivors at ICU discharge, days | 16·5 (10·5–26·5) | |
| Tracheostomy | 74/553 (13%) | |
| Reintubation | 70/546 (13%) | |
| Pneumothorax | 6/542 (1%) | |
| Complications | ||
| Thromboembolic complications | 118/552 (21%) | |
| Pulmonary embolism* | 75/552 (14%) | |
| Deep vein thrombosis | 25/552 (5%) | |
| Ischaemic stroke | 13/552 (2%) | |
| Myocardial infarction | 8/552 (1%) | |
| Systemic arterial embolism | 3/552 (1%) | |
| Acute kidney injury† | 259/553 (47%) | |
| Need for renal replacement therapy | 93/552 (17%) | |
| Clinical outcomes | ||
| ICU length of stay, days | 14·0 (8·0–24·0) | |
| In survivors at ICU discharge, days | 18·0 (10·0–30·0) | |
| Hospital length of stay, days | 21·0 (11·5–33·0) | |
| In survivors at hospital discharge, days | 29·0 (20·0–43·0) | |
| Mortality | ||
| Day 7 | 81/533 (16%) | |
| Day 28 | 186/530 (35%) | |
| Day 90 | 214/495 (43%) | |
| ICU | 203/530 (38%) | |
| Hospital | 210/496 (42%) | |
Data are median (IQR) or n/N (%). Outcomes were assessed up to day 28 when not indicated. ICU=intensive care unit.
*
Pulmonary embolism was defined when confirmed by chest CT angiography or when highly suspicious according to clinical assessment and treated accordingly by the attending physician.
†
Acute kidney injury was defined when at least one of the following criteria was met at any point within 28 days after intubation: (1) a 1·5-times increase in creatinine versus baseline; (2) an absolute creatinine increase of 26·5 μmol/L versus baseline; or (3) a urinary output of less than 0·5 mL/kg per h for more than 6 h.