Figure 2. Distinguishing features of transcript generation of PCGs and lncRNAs (A) LncRNA and (B) mRNAs: lncRNA genes are lowly expressed as fewer transcription factors (TFs) bind the promoter.

In addition, lncRNA TSS, exon and/or pA site more often associate with transposable elements (TEs), while TEs contribute mostly to UTRs and/or introns of mRNAs. In addition, mRNAs are more efficiently spliced.