Table 2.

Summary of deepening responses among patients with a response of very good partial response (VGPR) or partial response (PR) at study entry, by treatment arm, as assessed by the independent review committee.

	Ixazomib, n/N (%)	Placebo, n/N (%)	Relative risk (95% CI)	P value
Patients who deepened to CR/patients in VGPR at study entry	92/213 (43)	48/152 (32)	1.368 (1.034, 1.810)	0.025
Patients who deepened to VGPR or better/patients in PR at study entry	47/89 (53)	12/35 (34)	1.540 (0.935, 2.537)	0.063
Patients with any deepening response/patients in VGPR or PR at study entry	139/302 (46)	60/187 (32)	1.407 (1.102, 1.797)	0.004

P values determined using a Cochran–Mantel–Haenszel test stratified by response at study entry.

CI confidence interval, CR complete response, PR partial response, VGPR very good partial response.