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. 2020 Jul 30;34(11):2903–2913. doi: 10.1038/s41375-020-0996-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Data from the four subjects who experienced clinical responses (1 CRp, 2 MLFS, 1 PR) is shown. Blast percentages are shown on the left Y-axis, plasma R-2HG levels on the right Y-axis and treatment cycle number on the X-axis. Bone marrow blasts are illustrated with blue circles and peripheral blood blasts/leukocytes with red triangles. R-2HG levels are represented by gray bars and the R-2HG level associated with healthy individuals (138 ng/mL) is shown as black squares connected by a dotted black line.