Table 2.
Comparison of the neutralizing antibodies against SARS-CoV-2 and SARS-CoV
| Antibody/epitope | SARS-CoV-2 | SARS-CoV | References | ||
|---|---|---|---|---|---|
| IC50 | KD | KD | |||
| S-RBD epitope | |||||
| CR3022 Fab | NA | 115 ± 3 nM | 1.0 ± 0.1 nM | [14] | |
| CR3022 Ig | NA | < 0.1 nM | < 0.1 nM | [14] | |
| CB6 | 0.036 ± 0.007 μg /ml | 2.49 ± 1.65 nM | NA | [19] | |
| C105 | 0.0261 μg /ml | NA | NA | [24] | |
| B38 | 0.177 μg/ml | NA | NA | [18] | |
| H4 | 0.896 μg/ml | NA | NA | [18] | |
| B5 | 1.375 μg/ml | NA | NA | [18] | |
| H2 | 1.000 μg/ml | NA | NA | [18] | |
| H014 | 3 nM* | NA | NA | [17] | |
| 4A8 | 0.39 μg/ml | 92.7 nM | NA | [25] | |
|
REGN10933 REGN10987 |
0.0374 nM 0.0421 nM |
0.56 nM | NA | [23] | |
| EY6A | 20.7 μg/ml | 2 nM | NA | [22] | |
|
2–15, 1–57, 2–7, 4–20, 2–36, 1–20, 2–38, 2–4, 2–30 |
0.0007 to 0.209 μg/ml | NA | NA | [16] | |
| BD-217, BD-218, BD-236, BD-361, BD-368, BD-368–2, BD-395 | 0.015 to 1.6 μg/ml | 0.039 to 2.8 nM | NA | [21] | |
| S-NTD epitope | |||||
| 5–24, 4–18, 4–8, 5–7, 4–19, 1–87, 2–17, 1–68 | 0.007 to 0.109 μg/ml | NA | NA | [16] | |
| Other epitopes (quaternary epitopes) | |||||
|
2–43 2–51 |
0.003 μg/ml 0.007 μg/ml |
NA | NA | [16] | |
*pseudovirus neutralization assay, NA- not available