Table 1.
The Distributions of SLC1A1, SLC6A1, FAM131B, GPLD1, F2, GABRG2, GABRA1, and CACNG5 SNPs in Resistant and Responsive Patients
| Gene | rs Number | Model | Resistant Patients% | Responsive Patients% | P-value |
|---|---|---|---|---|---|
| SLC1A1 | rs10815018 | AA/AG/GG | 62.7/27.8/9.5 | 56.3/38.7/5 | 0.088 |
| AA/(AG+GG) | 62.7/37.3 | 56.3/43.7 | 0.27 | ||
| (AA+AG)/GG | 90.5/9.5 | 95/5 | 0.15 | ||
| SLC6A1 | rs10510403 | AA/AG/GG | 68.8/25.9/5.3 | 60.5/34.7/4.8 | 0.27 |
| AA/(AG+GG) | 68.8/31.2 | 60.5/39.5 | 0.14 | ||
| (AA+AG)/GG | 94.7/5.3 | 95.2/4.8 | 0.86 | ||
| FAM131B | rs4236482 | GG/GA/AA | 67.8/26.9/5.3 | 54/33.1/12.9 | 0.018 |
| GG/(AG+AA) | 67.8/32.2 | 54/46 | 0.016 | ||
| (GG+AG)/AA | 94.7/5.3 | 87.1/12.9 | 0.021 | ||
| GPLD1 | rs1126617 | CC/CT/TT | 59.1/36.3/4.7 | 56.6/39.3/4.1 | 0.86 |
| CC/(CT+TT) | 59.1/40.9 | 56.6/43.4 | 0.67 | ||
| (CT+CC)/TT | 95.3/4.7 | 95.9/4.1 | 0.81 | ||
| rs2076317 | AA/AG/GG | 49.2/42.7/8.1 | 48/42.1/9.9 | 0.86 | |
| AA/(AG+GG) | 49.2/50.8 | 48/52 | 0.83 | ||
| (AA+AG)/GG | 91.9/8.1 | 90.1/9.9 | 0.91 | ||
| F2 | rs1799963 | GG/AG/AA | 97.1/2.3/0.6 | 93.5/6.5/0 | 0.13 |
| GG/(AG+AA) | 97.1/2.9 | 93.5/6.5 | 0.15 | ||
| (GG+AG)/AA | 99.4/6 | 100/0 | 0.30 | ||
| GABRG2 | rs209337 | CC/CA/AA | 91.2/8.2/0.6 | 93.5/6.5/0 | 0.50 |
| CC/(CA+AA) | 91.2/8.2 | 93.5/6.5 | 0.47 | ||
| (CC+CA)/AA | 99.4/0.6 | 100/0 | 0.30 | ||
| GABRA1 | rs2279020 | AA/GA/GG | 27.4/56/16.7 | 41.3/43.8/14.9 | 0.044 |
| AA/(GA+GG) | 27.4/72.64 | 41.3/58.7 | 0.013 | ||
| (AA+GA)/GG | 83.3/16.7 | 85.1/14.7 | 0.68 | ||
| CACNG5 | rs740805 | AA/AG/GG | 91.2/7.7/1.2 | 82.9/17.1/0 | 0.017 |
| AA/(AG+GG) | 91.2/8.8 | 82.9/17.1 | 0.035 | ||
| (AA+AG)/GG | 98.8/1.2 | 100/0 | 0.14 |