Table 4.
The Distributions of SLC1A1, SLC6A1, FAM131B, GPLD1, F2, GABRG2, GABRA1, and CACNG5 SNPs in Patients with Focal Epilepsy (FE) and Healthy Controls
| Gene | rs Number | Model | FEP % | Control % | P-value |
|---|---|---|---|---|---|
| SLC1A1 | rs10815018 | AA/AG/GG | 53.8/37.8/8.4 | 51/39.2/9.8 | 0.84 |
| AA/(AG+GG) | 53.8/46.2 | 51/49 | 0.61 | ||
| (AA+AG)/GG | 91.6/8.4 | 90.2/9.8 | 0.66 | ||
| SLC6A1 | rs10510403 | AA/AG/GG | 64.2/32.5/3.2 | 63/31.6/5.4 | 0.63 |
| AA/(AG+GG) | 64.2/35.8 | 63/37 | 0.81 | ||
| (AA+AG)/GG | 96.8/3.2 | 94.6/5.4 | 0.33 | ||
| FAM131B | rs4236482 | GG/GA/AA | 62.1/27.4/10.5 | 62.5/33.8/3.7 | 0.023 |
| GG/(AG+AA) | 62.1/37.9 | 62.5/37.5 | 0.93 | ||
| (GG+AG)/AA | 89.5/10.5 | 96.3/3.7 | 0.008 | ||
| GPLD1 | rs1126617 | CC/CT/TT | 60.2/32.5/7.3 | 58.5/34.1/7.4 | 0.95 |
| CC/(CT+TT) | 60.2/39.8 | 58.5/41.5 | 0.76 | ||
| (CT+CC)/TT | 92.7/7.3 | 92.6/7.4 | 0.99 | ||
| rs2076317 | AA/AG/GG | 53.2/34.7/12.1 | 48.5/40.5/11 | 0.54 | |
| AA/(AG+GG) | 53.2/46.8 | 48.5/51.5 | 0.38 | ||
| (AA+AG)/GG | 87.9/12.1 | 89/11 | 0.76 | ||
| F2 | rs1799963* | GA/AG | 96.8/3.2 | 97/3 | 0.91 |
| GABRG2 | rs209337* | CC/CA | 96/4 | 93.3/6.7 | 0.27 |
| GABRA1 | rs2279020 | AA/GA/GG | 33/51.7/15.2 | 34.3/48.5/17.2 | 0.82 |
| AA/(GA+GG) | 33/67 | 34.3/65.7 | 0.80 | ||
| (AA+GA)/GG | 84.8/15.2 | 82.8/17.2 | 0.63 | ||
| CACNG5 | rs740805 | AA/AG/GG | 86.3/12.1/1.6 | 87.8/11.2/1 | 0.84 |
| AA/(AG+GG) | 86.3/13.7 | 87.8/12.2 | 0.67 | ||
| (AA+AG)/GG | 98.4/1.6 | 99/1 | 0.62 |
Note: *Monomorphic SNP.