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. 2020 Oct 24;91:383–392. doi: 10.1016/j.bbi.2020.10.019

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© 2020 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Manhattan plots showing the associations between COVID-19 and pre-existing comorbidities. (A) Comparison between COVID-19 patients and all other UKB participants. The significance threshold with Bonferroni correction (p < 5.13 × 10^-5) is represented by the red dashed line. Labelled phenotypes are over-represented in COVID-19 patients and remain nominally significant after the correction for bias in the testing sample. (B) Comparison between COVID-19 patients and those tested negative. Nominal significance (p < 0.05) is indicated by the red dashed line. Phenotypes over-represented in COVID-19 patients are labeled. Results based on males, females, and combined samples are shown with different shapes. The size of the shape is proportional to the odds ratio. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)