Fig. 4.

Associations between (A) ACE2 and (B) TMPRSS2 genetic variants and COVID-19. Each dot is a tag SNP. SNPs associated with gene expression are indicated in red. The nominal significance cutoff (p < 0.05) is represented by the gray dashed line, while the significance threshold with Bonferroni correction for the number of SNPs tested is indicated by the red dashed line. The model of the longest transcript is shown at the bottom while the genic region, covering all transcripts, is shown as an arrow. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)