Table 2.
List of tag SNPs at TMPRSS2 associated with COVID-19 at the nominal significance level.
| SNP | Position on Chr21 | REF/ALT | EAF (Non/Neg/Pos) | Pos vs. Non |
Pos vs. Neg |
||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | ||||
| rs7282236 | 41519797 | A/G | 0.751/0.742/0.777 | 1.203 (1.06,1.36) | 0.0033 | 1.327 (1.14,1.54) | 0.00023 |
| rs114837856 | 41475211 | A/T | 0.494/0.492/0.477 | 0.856 (0.76,0.97) | 0.013 | 0.842 (0.72,0.98) | 0.025 |
| rs56695953 | 41497808 | A/G | 0.824/0.824/0.807 | 0.864 (0.76,0.98) | 0.027 | 0.874 (0.74,1.03) | 0.104 |
| rs8134657 | 41521981 | A/G | 0.905/0.910/0.891 | 0.839 (0.71,0.98) | 0.033 | 0.765 (0.63,0.94) | 0.009 |
| rs915823 | 41479527 | C/A | 0.798/0.796/0.808 | 1.140 (1.00,1.29) | 0.050 | 1.186 (1.01,1.39) | 0.033 |
| rs35050484 | 41471079 | A/G | 0.963/0.967/0.952 | 0.784 (0.61,1.00) | 0.050 | 0.681 (0.50,0.93) | 0.016 |
| rs56379149 | 41531825 | T/G | 0.529/0.538/0.508 | 0.905(0.82,1.00) | 0.055 | 0.863 (0.76,0.98) | 0.018 |
SNP: single nucleotide polymorphism; REF: reference allele; ALT: alternative allele; EAF: effect allele frequency (alternative allele is the effect allele); Non: non-positive, all other UK Biobank participant that are untested or tested negative; Neg: COVID-19 tested negative; Pos: COVID-19 tested positive; OR: odds ratio; CI: confidence interval.