Table 2.
miRNA-mRNA regulatory pairs identified by bioinformatics prediction and RNA-seq analysis.
| DE miRNA | DE mRNA | |||||
|---|---|---|---|---|---|---|
| Name | Log2FC | p-value | Name | Log2FC | p-value | mRNA description |
| ssc-miR-370 | 6.178595091 | 2.07828E-05 | SCD5 | −1.237577 | 0.009508 | Stearoyl-CoA desaturase 5 |
| ssc-miR-370 | ITGB1BP2 | −1.472781 | 0.014478 | Integrin subunit beta 1 binding protein 2 | ||
| ssc-miR-370 | BMPR1B | −1.11218 | 2.13E-06 | Bone morphogenetic protein receptor type 1B | ||
| ssc-miR-218b | 5.689812352 | 3.25407E-21 | THBS1 | −2.471627 | 1.02E-24 | Thrombospondin-1 |
| ssc-miR-218 | 5.688618566 | 3.02648E-21 | THBS1 | −2.471627 | Thrombospondin-1 | |
| ssc-miR-218-5p | 5.688618566 | 3.02648E-21 | THBS1 | −2.471627 | Thrombospondin-1 | |
| ssc-miR-758 | 4.596925271 | 5.84363E-15 | FGL2 | −1.910608 | 0.005372 | Fibrinogen like 2 |
| ssc-miR-758 | TPM1 | −1.50469 | 7.95E-16 | Tropomyosin 1 | ||
| ssc-miR-758 | BMPR1B | −1.11218 | 2.13E-06 | Bone morphogenetic protein receptor type 1B | ||
| ssc-miR-381-3p | 4.19198935 | 2.68577E-56 | PECAM1 | −1.015514 | 0.044941 | Platelet endothelial cell adhesion molecule 1 |
| ssc-miR-9-1 | 3.922280627 | 2.01609E-24 | BMPR1B | −1.11218 | 2.13E-06 | Bone morphogenetic protein receptor type 1B |
| ssc-miR-9-2 | 3.922280627 | 2.01609E-24 | BMPR1B | −1.11218 | Bone morphogenetic protein receptor type 1B | |
| ssc-miR-9 | 3.922280627 | 2.01609E-24 | BMPR1B | −1.11218 | Bone morphogenetic protein receptor type 1B | |
| ssc-miR-133a-5p | 3.875394952 | 7.87582E-07 | ITGB3 | −2.86968 | 1.99E-20 | Integrin subunit beta 3 |
| ssc-miR-326 | 3.528143119 | 0.000584564 | TNC | −2.471314 | 0.009831 | Tenascin C |
| ssc-miR-326 | BMPR1B | −1.11218 | 2.13E-06 | Bone morphogenetic protein receptor type 1B | ||
| ssc-miR-326 | ITGB3 | −2.86968 | 1.99E-20 | Integrin subunit beta 3 | ||
| ssc-miR-326 | FMOD | −4.940557 | 5.15E-18 | Fibromodulin | ||
| ssc-miR-222 | 2.522752887 | 7.57707E-31 | THBS1 | −2.471627 | 1.02E-24 | Thrombospondin-1 |
| ssc-miR-222 | SCD5 | −1.237577 | 0.009508 | Stearoyl-CoA desaturase 5 | ||
| ssc-miR-222 | BMPR1B | −1.11218 | 2.13E-06 | Bone morphogenetic protein receptor type 1B | ||
| ssc-miR-2483 | 2.460120488 | 1.861E-12 | SCD5 | −1.237577 | 0.009508 | Stearoyl-CoA desaturase 5 |
| ssc-miR-708-5p | 2.129951111 | 3.82258E-14 | PPP2R1B | −1.18985 | 2.41E-11 | Protein phosphatase 2, regulatory subunit A, beta |
| ssc-miR-708-5p | PECAM1 | −1.015514 | 0.044941 | Platelet endothelial cell adhesion molecule 1 | ||
| ssc-miR-210 | 2.062574633 | 1.46791E-18 | BMPR1B | −1.11218 | 2.13E-06 | Bone morphogenetic protein receptor type 1B |
| ssc-miR-708-3p | 2.039435793 | 3.15227E-30 | GBP1 | −3.500134 | 0.043545 | Guanylate-binding protein-1 |
| ssc-miR-139-3p | 2.004837087 | 9.58703E-05 | PPP2R1B | −1.18985 | 2.41E-11 | Protein phosphatase 2, regulatory subunit A, beta |
| ssc-miR-204 | 1.735135479 | 0.011872702 | XIRP2 | −4.581904611 | ||
| ssc-miR-204 | FMOD | −4.940557268 | 5.15E-18 | Fibromodulin | ||
| ssc-miR-145-5p | 1.647812344 | 0.012650534 | TNC | −2.471314 | 0.009831 | Tenascin C |
| ssc-miR-145-5p | PPP2R1B | −1.18985 | 2.41E-11 | Protein phosphatase 2, regulatory subunit A, beta | ||
| ssc-miR-139-5p | 1.332128509 | 6.31401E-07 | PPP2R1B | −1.18985 | 2.41E-11 | Protein phosphatase 2, regulatory subunit A, beta |
| ssc-miR-2366 | 1.317737461 | 0.014450992 | BMPR1B | −1.11218 | 2.13E-06 | Bone morphogenetic protein receptor type 1B |
| ssc-miR-2366 | PPP2R1B | −1.18985 | 2.41E-11 | Protein phosphatase 2, regulatory subunit A, beta | ||
| ssc-miR-2366 | TPM1 | −1.50469 | 7.95E-16 | Tropomyosin 1 | ||
| ssc-miR-2366 | PECAM1 | −1.015514 | 0.044941 | Platelet endothelial cell adhesion molecule 1 | ||
| ssc-miR-2366 | BMPR1B | −1.11218 | 2.13E-06 | Bone morphogenetic protein receptor type 1B | ||
| ssc-miR-2366 | ITGB3 | −2.86968 | 1.99E-20 | Integrin subunit beta 3 | ||
| ssc-miR-141 | 1.186293739 | 0.003239735 | SCD5 | −1.237577 | 0.009508 | Stearoyl-CoA desaturase 5 |
| ssc-miR-486 | 1.157635382 | 0.01879132 | TPM1 | −1.50469 | 7.95E-16 | Tropomyosin 1 |
| SCD5 | −1.237577 | 0.009508 | Stearoyl-CoA desaturase 5 | |||
| ssc-miR-455-3p | -3.9566311 | 1.55911E-27 | TSPO | 2.0494085 | 1.28E-22 | Translocator protein |
| ssc-miR-455-5p | -3.63262127 | 1.03633E-83 | CLIC5 | 2.0277318 | 0.014776 | Chloride intracellular channel 5 |
| ssc-miR-455-5p | ADM | 1.5099872 | 0.0019 | Adrenomedullin receptor binding | ||
| ssc-miR-503 | -2.58773042 | 1.25655E-13 | UPK3A | 2.3662439 | 0.000114 | Uroplakin-3a |
| ssc-miR-450b-3p | -2.11042317 | 0.000111361 | SERPINE1 | 1.8087562 | 0.023176 | Serine protease inhibitor |
| ssc-miR-542-5p | -2.05471325 | 0.001828484 | SLA-1 | 2.2493011 | 7.35E-13 | Swine leukocyte antigen 1 |
| ssc-miR-33b-3p | -1.43038729 | 0.022697288 | NOTCH4 | 1.5662127 | 8.76E-05 | Neurogenic locus notch homolog protein 4 |
| ssc-miR-33b-3p | CLIC5 | 2.0277318 | 0.014776 | Chloride intracellular channel 5 | ||
| ssc-miR-33b-3p | HOPX | 1.5568756 | 1.76E-07 | Homeodomain only protein x | ||
| ssc-miR-33b-3p | CLIC5 | 2.0277318 | 0.014776 | Chloride intracellular channel 5 | ||
| ssc-miR-30c-1-3p | -1.38003544 | 1.60307E-05 | NPL | 1.2288895 | 4.61E-08 | N-acetylneuraminate pyruvate lyase |
| ssc-miR-30c-1-3p | CLIC5 | 2.0277318 | 0.014776 | Chloride intracellular channel 5 | ||
| ssc-miR-30c-1-3p | BGN | 6.0384272 | 6.5E-186 | Biglycan | ||
| ssc-miR-187 | -1.31451094 | 0.027568031 | CEBPA | 2.6207539 | 2.75E-12 | CCAAT Enhancer Binding Protein alpha |
| ssc-miR-4331-5p | -1.19068004 | 1.75792E-05 | ITGB2 | 2.3291911 | 1.11E-10 | Integrin subunit beta 2 |
| ssc-miR-107 | -1.060541296 | 5.86371E-06 | MAPK12 | 1.376323493 | 2.06E-09 | Mitogen-activated protein kinase 12 |
| ssc-miR-107 | TPI1 | 1.010227085 | 8.48E-08 | Triosephosphate isomerase 1 | ||
| ssc-miR-107 | ITGB2 | 2.329191133 | 1.11E-10 | Integrin subunit beta 2 | ||
| ssc-miR-4334-3p | -1.048828923 | 0.019963139 | CDH1 | 1.183998589 | 1.61E-08 | Cadherin 1 |
| ssc-miR-4334-3p | SLC26A11 | 1.615163318 | 4.34E-06 | Solute carrier family 26 member 11 | ||
| ssc-miR-4334-3p | THY1 | 1.409988419 | 0.001799 | Thy-1 cell surface antigen | ||
| ssc-miR-4334-3p | COL1A1 | 1.706614176 | 1.21E-09 | Collagen type I alpha 1 chain | ||
| ssc-miR-4334-3p | SERPINE1 | 1.808756158 | 0.023188 | Serpin family E member 1 | ||
| ssc-miR-532-3p | -1.012120672 | 0.002619262 | SLC16A3 | 1.260691201 | 2.33E-11 | Solute carrier family 16 member 3 |
| ssc-miR-532-3p | COL1A1 | 1.706614176 | 1.21E-09 | Collagen type I alpha 1 chain | ||
| ssc-miR-532-3p | BGN | 6.03842722 | 6.5E-186 | Biglycan | ||
| ssc-miR-532-3p | FLVCR2 | 4.988102404 | 0.000774 | Feline leukemia virus subgroup C cellular receptor family member 2 | ||
| ssc-miR-532-3p | CLIC5 | 2.0277318 | 0.014776 | Chloride intracellular channel 5 | ||
| ssc-miR-532-3p | CEBPA | 2.6207539 | 2.75E-12 | CCAAT Enhancer Binding Protein alpha | ||
| ssc-miR-532-3p | TPI1 | 1.010227085 | 8.48E-08 | Triosephosphate isomerase 1 | ||
| ssc-miR-532-3p | THY1 | 1.409988419 | 0.001799 | Thy-1 cell surface antigen | ||