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. 2020 Oct 23;10:18166. doi: 10.1038/s41598-020-75321-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic ablation of adipocyte ATGL improves insulin sensitivity during HS (a) glucose, (b) glycerol, and (c) NEFA levels in serum from WT^fl/fl and FATA^−/− mice fasted 4 h then subjected to sham or HS. After 30 min of sham or HS, WT^fl/fl or FATA^−/− mice were injected with saline or 0.5 U insulin in the inferior vena cava, and tissues were harvested after 4 min. Representative immunoblots and quantitation for (d) white adipose tissue (WAT, epididymal), (e) liver, and (f) skeletal muscle (SKM, gastrocnemius). N = 3–12. Data are shown as mean ± SEM. **P < 0.01 and ***P < 0.001, as indicated. For (a–c), statistical analyses were performed using two-way ANOVA. For (d–f), image quantitations were normalized by setting largest value in each immunoblot to 100. Statistical analyses on relative values were performed using three-way ANOVA. All comparisons differing by one variable were made and adjusted for with ANOVA, and all significant comparisons are denoted as such.