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. 2020 Oct 23;10:18177. doi: 10.1038/s41598-020-74866-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of the major components of Acanthopanax senticosus HARMS (chlorogenic acid [CHA], ( +)-syringaresinol di–O–β-D-glucoside [SYG], and a mixture of both [MIX]) and cloxazolam (CLO) on autonomic nervous system control of heart rate in the improved elevated beam walking (IEBW) test. Power spectrum analysis of heart rate variability in the home cage and in the IEBW test. (A) Normalized low-frequency (LF) power (LFnu) reflects sympathetic nervous system activity. (B) Normalized high-frequency (HF) power (HFnu) reflects parasympathetic nervous system activity. (C) LF/HF indicates the balance between sympathetic and parasympathetic nervous system activities. Data are presented as means ± SE; n = 5–8; *p < 0.05, **p < 0.01 vs. the control (Cont) group (Dunnett’s t-test), ^#p < 0.05 versus each home cage (paired t-test).