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. 2020 Oct 23;10:18177. doi: 10.1038/s41598-020-74866-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schedule of the open field test (OFT). After 1 week of pre-housing, rats were administered 1 mL of each reagent. On the test day, rats were administered the test agents 0.5 or 2 h before the OFT. Rats were then placed in the apparatus and allowed to explore the area freely for 10 min.