Figure 4.

Fibroblast-selective DR3-deficiency attenuates intestinal fibroblast migration ex vivo: (A) Number of adherent cells/visual field indicated during adhesion assays at time points of 20 min and 80 min for fibroblasts isolated ex vivo from adoptive transfer Rag^−/−, Rag^−/−Dr3^−/−, or Rag^−/−Dr3^∆Col1a2 recipient mice. (B) Representative images of gap-closure assay after simulated wound on fibroblasts isolated ex vivo from adoptive transfer Rag^−/−, Rag^−/−Dr3^−/−, or Rag^−/−Dr3^∆Col1a2 recipient mice at initial wound (t₀) and 8 h after migration (t₈) with relative % area of gap closed quantitated; representative of 3 independent experiments; * indicates p < 0.05.