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. 2020 Oct 23;10:18189. doi: 10.1038/s41598-020-75168-5

Figure 5.

Figure 5

Transcriptomic analysis of Tl1a-stimulated intestinal fibroblasts identifies cytoskeletal contraction-related genes and the Rho signaling pathway: (A) Heatmap generated from transcriptome analysis of isolated cecal fibroblasts from three individual mice shown as untreated (a, b, c) and Tl1a-treated (a + Tl1a, etc.) pairs; BRB array tools, (brb.nci.nih.gov/BRB-ArrayTools). (B) Independent validation cohort was used to confirm several genes in the index group; matched pairs displayed as untreated (ut) or TL1A-treated fibroblasts with direct increase in expression for each sample shown, * indicates p < 0.05. (C) Genetic ontology pathway enrichment of differentially expressed genes induced by TL1A in (A).