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. 2020 Oct 23;10:18189. doi: 10.1038/s41598-020-75168-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020

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Inhibition of Rho kinase pathway modulates morphology and function of intestinal fibroblasts: (A) Gap closure assay and morphology of migrating intestinal fibroblasts isolated from three individual Tl1a-Tg mice, in the presence (or absence) of 25uM ROCK inhibitor Y27632, shown as treated and un-treated pairs. Blue arrow denotes direction of migration with solid vs dotted line highlighting cell extensions at migrating front; upper panels 100× objective, lower panels 200× objective. (B) Collagen contraction assay of intestinal fibroblasts isolated and treated as in (A). (C) Collagen contraction assay of WT or DR3^−/− intestinal fibroblasts treated with 100 ng/mL mouse recombinant Tl1a, 25uM ROCK inhibitor Y27632, or both. Data normalized to genotype control with bars representative of means; * indicates p < 0.05, **p < 0.01.