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. 2020 Oct 23;11(10):902. doi: 10.1038/s41419-020-03123-3

Fig. 6. The miR-30a-5p/CLCF1 axis is important in regulating metabolism of glucose in HCC cells resistant to sorafenib.

Fig. 6

a Glucose consumption in HepG2-S-R cells transfected with miR-30a-5p with or without CLCF1 cotransfection. b Lactate production in HepG2-S-R cells transfected with miR-30a-5p with or without CLCF1 cotransfection. c Relative ATP luminescence in HepG2-S-R cells transfected with miR-30a-5p with or without CLCF1 cotransfection. d Left, real-time measurement of extracellular acidification rate (ECAR) in HepG2-S-R cells transfected with miR-30a-5p with or without CLCF1 cotransfection. The value of glycolysis (Middle) and glycolytic capacity (Right) in the indicated cells. e Relative mRNA level of GLUT3, HK2, and PDK1 in HepG2-S-R cells transfected with miR-30a-5p with or without CLCF1 cotransfection. f Relative protein level of GLUT3, HK2, and PDK1 in HepG2-S-R cells transfected with miR-30a-5p with or without CLCF1 cotransfection. All data are mean ± SD of three separate experiments. ** P < 0.01.