Fig. 3. Palladium-catalyzed cascade reaction of ammonium salts with aryl halides.

Standard reaction conditions: 1 (0.2 mmol), 2 (0.2 mmol), Cs₂CO₃ (0.4 mmol), PdBr₂ (0.01 mmol), L1 (0.02 mmol), toluene (2.5 mL), the reaction mixture was performed at 110 °C under argon atmosphere for 22 h, isolated yield, the diastereoselectivity of 4e, 4p, and 4ac was determined by crude ¹⁹F NMR analyses. ^†The reaction mixture was performed at 90 °C. ^‡1 mol% PdBr₂ and 2 mol% L1 were used. ^§10 mol% PdBr₂ and 20 mol% L1 were used. ^¶1 (0.2 mmol), 2 (0.1 mmol) were used. ^#2 mol% PdBr₂ and 4 mol% L1 were used.