Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 23;6:33. doi: 10.1038/s41540-020-00153-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — The wide variety of lipid species was simplified by considering all carry a representative acyl chain distribution instead of a mix with different acyl chain configurations. This simplification considerably reduces the complexity of the model while at the same time maximizing the amount of quantitative information. a Cholesterol is directly incorporated in the membrane, as well as sphingomyelin (SM), for which all the different fatty acid chains proportions have been considered. Phosphatidylcholine is imported using ATP and either goes to build the membrane or it is degraded into its fatty acid chains and glycerol-phosphocholine (G3PC). All the fatty acids introduced in the medium (C16:0, C16:1, C18:0, C18:1, C18:2) will be linked to an acyl-carrier protein (ACP) at the expense of ATP. The ACP then releases the fatty acid chain to glycerol 3-phosphate (glyc3p) and the product, reacting with the ACP carrying fatty acids, leads to the production of phosphatidic acid (PA). b PA then undergoes synthesis of phosphatidylglycerol (PG) or glycolipids.