Fig. 2.

Compound 7f had a more inhibitory effect on NSCLC than PTX. (A) The docking posture of PTX and compound 7f with TS (PDB ID: 1JUJ): The green structure was PTX, while the yellow was compound 7f. (B): a. and b. The effect of compound 7f and PTX on hTS enzyme activity or the proliferation of A549 cells was compared at each concentration point. c. The inhibitory effects of compounds 7f and PTX on the cell viability of five cancer cells at each concentration point. d. Comparison of drug selectivity index of compound 7f and PTX against five healthy cells (where *p < 0.05, **p < 0.01 and ***p < 0.005 compared to control). (C) Inhibition of cell viability of eight NSCLC cells by compound 7f at different concentrations. (D) Colony-forming assay shows compound 7f could inhibit A549 or PC-9 cell proliferation.