Table 3.
Selectivity index (SI) of compound 7f, and PTX.
| Compounds | SIm |
||||
|---|---|---|---|---|---|
| HPAEpiC | IOSE80 | GES-1 | MCF10A | LO2 | |
| 7a | 4.582051 | – | – | 7.741192 | – |
| 7b | 7.587242 | 6.284264 | 4.832857 | 4.574427 | – |
| 7c | 13.02167 | 4.972332 | 3.111901 | 4.898239 | 4.938776 |
| 7d | 4.265271 | 3.616341 | 3.5231 | 6.254355 | 4.375796 |
| 7e | 15.23358 | 7.668016 | 6.241379 | 5.831325 | 5.047091 |
| 7f | 21.30769 | 14.14679 | 17.93651 | 13.10323 | 9.762136 |
| 7 g | 17.85185 | 11.27711 | 14.61212 | 13.97409 | 7.007273 |
| 7 h | 7.620408 | 7.641026 | – | – | – |
| 7i | – | – | 11.97307 | 9.070284 | – |
| 7j | 5.177019 | – | – | – | – |
| 7 k | 7.141361 | 2.962687 | 2.852804 | 2.453012 | 3.029126 |
| 7 l | 12.36522 | 3.248252 | 2.716599 | 2.49345 | 1.648402 |
| 7 m | 7.754011 | 3.28877 | 2.806522 | 0.940754 | 2.08871 |
| PTX | 8.036474 | 4.241121 | 3.089855 | 7.200957 | 8.512064 |
m: SI = CC50/IC50.