Table 3.
Table shows the list of genes influencing various molecular targets that are modulated by EGCG
| Molecular targets | Expression status | Modulated genes |
|---|---|---|
| Cell cycle regulation | Downregulated | CCNB1, CCNB2, CCND1, CCND2, CDKN1A |
| Proliferation | Upregulated | TP53, TP73, PTEN, TP53I3 |
| Downregulated | TERT | |
| Metastasis | Upregulated | CDH1, SOCS1 |
| Downregulated | COLIA1, MMP1, MMP10, MMP2, MMP7 | |
| PI3K pathway | Downregulated | PIK3C2B, PIK3CA, PIK3CB |
| Wnt pathway | Downregulated | WNT2 |
| MAPK pathway | Upregulated | PTPRR |
| Downregulated | ELK1, MAPK8 | |
| Inflammation markers | Downregulated | IL6, IL1A, IL2 |
| DNA methyltransferases | Downregulated | DNMT3B DNMT1, DNMT3A |
| Histone deacetylases | Downregulated | HDAC11, HDAC5, HDAC7, HDAC6 |
| Histone methylases | Upregulated | SETD7 |
| Downregulated | PRMT7, PRMT6, | |
| Demethylases | Downregulated | KDM5C, KDM4A |
| Histone phosphorylases | Downregulated | AURKC, AURKB, AURKA |
| Histone ubiquitinases | Downregulated | UBE2A, UBE2B |
| Tumour suppressor genes | TSGs which showed decreased promoter methylation | APC, CDH1, CDH13, DAPK1, FHIT, GSTP1, MGMT, PTEN, RARB, RASSF1, SOC51, TIMP3 |
| TSGs whose expression was restored | TP73, PTEN, SOCS1, CDH1, RARβ, DAPK1 |