Table 1.
Baseline characteristics of patients with atrial fibrillation treated with and without apixaban
| Apixaban (n = 1349) | No apixaban (n = 3666) | p value | |
|---|---|---|---|
| Mean age (years) | 73.9 | 74.3 | 0.2 |
| Age ≥ 75 years | 54.9% | 58.1% | 0.06 |
| Women | 48.0% | 43.4% | < 0.01 |
| Paroxysmal AF | 52.2% | 43.8% | < 0.0001 |
| Persistent AF | 27.2% | 20.5% | |
| Permanent AF | 20.7% | 35.7% | |
| Prior cardioversion | 30.1% | 27.6% | 0.8 |
| Prior pulmonary vein isolation | 7.0% | 8.5% | 0.09 |
| Prior left atrial appendage occlusion | 0.4% | 1.1% | < 0.05 |
| Prior pacemaker | 13.2% | 16.7% | < 0.01 |
| Prior ICD and CRT | 4.9% | 5.0% | 0.9 |
| Coronary artery disease | 29.7% | 35.5% | < 0.01 |
| Prior myocardial infarction | 10.1% | 11.7% | 0.5 |
| Heart failure | 33.0% | 39.7% | < 0.001 |
| Reduced left ventricular function | 39.5% | 45.5% | < 0.01 |
| Prior stroke | 11.5% | 11.0% | 0.6 |
| Prior TIA | 5.7% | 4.6% | 0.12 |
| Diabetes mellitus | 27.5% | 30.7% | < 0.05 |
| Hypertension | 84.7% | 87.0% | < 0.05 |
| GFR < 60 ml/min | 37.3% | 38.6% | 0.48 |
| Prior major ISTH bleeding | 1.4% | 2.5% | < 0.05 |
| Prior moderate or minor bleeding | 3.6% | 3.7% | 0.8 |
| Mean CHADS-VASc score | 3.76 | 3.89 | < 0.01 |
| CHADS-VASc SCore | |||
| 0 | 1.6% | 1.9% | |
| 1 | 6.2% | 4.9% | |
| 2–4 | 60.9% | 58.7% | |
| > 4 | 31.4% | 34.5% | |
| Mean HAS-BLED score | 2.14 | 2.30 | < 0.001 |
| HAS-BLED score | |||
| 0–1 | 21.7% | 16.4% | |
| 2 | 48.4% | 46.6% | |
| > 3 | 29.9% | 37.0% |