Table 4.
Plasma toxicokinetic parameters following a single gavage administration of 150 mg/kg [14C]triclocarban in male and female ratsa. Data are presented based on both the [14C] triclocarban-derived total radioactivity and parent triclocarban concentration.
| Parameter | Male | Female |
|---|---|---|
| [14C] Triclocarban-derived total radioactivitya | ||
| Cmax (ng/mL) | 28100 | 43400 |
| Tmax (h) | 16.0 | 16.0 |
| Lamda half-life (h) | 18.8 | 8.58 |
| AUCINF_PRED (h*ng/mL) | 885000 | 659000 |
| Triclocarban b | ||
| Cmax-pred (ng/mL) | 1914 | 1834 |
| Tmax-pred (h) | 3.4 | 3.3 |
| K01 half-Life (h) | 2.32 | 2.26 |
| K10 half-Life (h) | 2.32 | 2.27 |
| Cl/F (mL/h/kg) | 8620 | 9207 |
| V/F (mL/kg) | 28860 | 30161 |
| AUC (h*ng/mL) | 17402 | 16293 |
| Percent of AUCtriclocarban/AUCtotal radioactivity | 1.96 | 2.47 |
a
Based on non-compartmental analysis of [14C]-derived total radioactivity.
b
Based on one-compartment model with first order input and output.