Skip to main content
. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Trends Cell Biol. 2020 Sep 6;30(11):904–915. doi: 10.1016/j.tcb.2020.08.005

Figure 5. PRCD is required for the efficient flattening of newly forming discs.

Figure 5.

(A) An electron micrograph of PRCD knockout rods reveals the presence of ectosomes accumulated at the outer segment base. (B) An image of a 1 nm z-section from a 3D electron tomogram taken at the base of a PRCD knockout rod outer segment showing that newly forming discs fail to efficiently flatten, forming bulges filled with cytoplasm (marked by arrowheads). These bulges shed as ectosomes before disc enclosure, allowing mature discs to be flat inside the outer segment. (C) An illustration of the PRCD knockout phenotype. Images are adapted from [61].