Table 3.
Immunohistochemical analysis of NTRK-rearranged thyroid carcinomas.
| Case # | TTF1 | PAX8 | Thyroglobulin | HBME1 | BRAF V600E | Mammaglobin | S100 | GATA3 |
|---|---|---|---|---|---|---|---|---|
| 1 | ++ | ++ | + | ++ | − | − | − | − |
| 2 | ++ | ++ | ++ | ++ | − | − | − | − |
| 3 | ++ | ++ | ++ | ++ | − | − | − | − |
| 4 | ++ | ++ | ++ | ++ | − | − | − | − |
| 5 | ++ | ++ | ++ | ++ | − | − | − | − |
| 6 | ++ | ++ | ++ | ++ | − | − | − | − |
| 7 | ++ | ++ | + | + | Naa | − | − | − |
| 8 | ++ | ++ | ++ | ++ | − | − | − | − |
| 9 | ++ | ++ | ++ | ++ | − | − | − | − |
| 10 | ++ | ++ | ++ | ++ | − | − | − | − |
| 11 | + weak | − | − | na | − | ++ | ++ | ++ |
na not available, ++ diffuse, + focal, − negative.
a
Although BRAF V600E IHC is not available for case 7, SNaPshot testing was negative for BRAF V600E mutation.