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. 2020 Oct 23;40(10):BSR20201725. doi: 10.1042/BSR20201725

Table 2. GO and KEGG enrichment analysis of candidate IRGs in IV CRC ranked by P value (Top 5).

Categor y GO or KEGG ID GO or KEGG term P.adjust Count
BP GO:0002449 Lymphocyte-mediated immunity 4.15E-91 131
BP GO:0006959 Humoral immune response 1.15E-90 131
BP GO:0002460 Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 3.01E-86 128
BP GO:0006958 Complement activation, classical pathway 1.90E-82 85
BP GO:0002455 Humoral immune response mediated by circulating immunoglobulin 1.91E-82 88
CC GO:0019814 Immunoglobulin complex 3.12E-99 122
CC GO:0042101 T-cell receptor complex 2.74E-98 90
CC GO:0098802 Plasma membrane receptor complex 1.57E-80 111
CC GO:0009897 External side of plasma membrane 3.00E-75 120
CC GO:0042571 Immunoglobulin complex, circulating 1.33E-51 49
MF GO:0048018 Receptor ligand activity 4.71E-97 197
MF GO:0003823 Antigen binding 1.67E-94 94
MF GO:0005125 Cytokine activity 6.20E-86 100
MF GO:0008083 Growth factor activity 1.18E-68 78
MF GO:0005126 Cytokine receptor binding 4.80E-65 94
KEGG hsa04060 Cytokine–cytokine receptor interaction 1.84E-98 136
KEGG hsa04061 Viral protein interaction with cytokine and cytokine receptor 5.58E-36 50
KEGG hsa04080 Neuroactive ligand–receptor interaction 4.31E-27 76
KEGG hsa04062 Chemokine signaling pathway 1.05E-16 45
KEGG hsa04650 Natural killer cell–mediated cytotoxicity 2.39E-16 37