Table 3. Stratified analysis of rs351855 polymorphisms by ethnicity and cancer type.
| n | Genetic model | Association test | Heterogeneity test | Egger’s test P | Begg’s test P | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | Z | P | χ2 | I2 (%) | P | |||||
| Caucasian | 15 | AG vs GG | 0.97 (0.84–1.12) | 0.42 | 0.672 | 26.56 | 47.3 | 0.002 | 0.162 | 0.586 |
| AA vs GG | 1.11 (0.95–1.29) | 1.30 | 0.193 | 19.36 | 27.7 | 0.152 | 0.331 | 0.216 | ||
| AG+AA vs GG | 0.96 (0.83–1.12) | 0.47 | 0.636 | 35.15 | 57.3 | 0.002 | 0.257 | 0.471 | ||
| AA vs AG+GG | 1.09 (0.94–1.26) | 1.09 | 0.278 | 16.49 | 15.1 | 0.284 | 0.118 | 0.125 | ||
| A vs G | 1.03 (0.92–1.15) | 0.43 | 0.666 | 30.34 | 53.9 | 0.007 | 0.789 | 0.458 | ||
| Asian | 17 | AG vs GG | 0.96 (0.82–1.12) | 0.56 | 0.572 | 55.29 | 71.1 | 0.000 | 0.023 | 0.039 |
| AA vs GG | 1.1 (0.84–1.44) | 0.72 | 0.470 | 94.65 | 83.1 | 0.000 | 0.636 | 0.510 | ||
| AG+AA vs GG | 0.98 (0.81–1.17) | 0.27 | 0.786 | 86.32 | 81.5 | 0.000 | 0.092 | 0.070 | ||
| AA vs AG+GG | 1.13 (0.91–1.40) | 1.12 | 0.262 | 76.08 | 79.0 | 0.000 | 0.832 | 0.458 | ||
| A vs G | 1.01 (0.87–1.16) | 0.11 | 0.913 | 119.83 | 86.6 | 0.000 | 0.352 | 0.217 | ||
| Breast cancer | 7 | AG vs GG | 0.94 (0.66–1.33) | 0.35 | 0.729 | 26.00 | 76.9 | 0.000 | 0.050 | 0.099 |
| AA vs GG | 1.03 (0.48–2.22) | 0.08 | 0.939 | 44.25 | 86.4 | 0.000 | 0.358 | 0.186 | ||
| AG+AA vs GG | 0.91 (0.58–1.44) | 0.40 | 0.691 | 50.88 | 88.2 | 0.000 | 0.135 | 0.099 | ||
| AA vs AG+GG | 1.05 (0.56–1.96) | 0.16 | 0.877 | 31.50 | 81.0 | 0.000 | 0.540 | 0.176 | ||
| A vs G | 0.92 (0.61–1.38) | 0.40 | 0.690 | 71.30 | 91.6 | 0.000 | 0.233 | 0.072 | ||
| Prostate cancer | 6 | AG vs GG | 1.16 (1.02–1.32) | 2.25 | 0.025 | 2.91 | 0.0 | 0.714 | 0.422 | 0.188 |
| AA vs GG | 1.60 (0.98–2.61) | 1.90 | 0.058 | 13.39 | 62.7 | 0.020 | 0.378 | 0.462 | ||
| AG+AA vs GG | 1.20 (1.06–1.35) | 2.89 | 0.004 | 1.67 | 0.0 | 0.892 | 0.639 | 0.851 | ||
| AA vs AG+GG | 1.56 (0.92–2.65) | 1.63 | 0.103 | 17.29 | 71.1 | 0.004 | 0.452 | 0.624 | ||
| A vs G | 1.22 (1.06–1.41) | 2.81 | 0.005 | 7.55 | 33.8 | 0.183 | 0.279 | 0.260 | ||
| Gastrointestinal cancer | 7 | AG vs GG | 0.92 (0.80–1.06) | 1.17 | 0.243 | 6.73 | 10.9 | 0.346 | 0.071 | 0.090 |
| AA vs GG | 1.06 (0.88–1.28) | 0.63 | 0.528 | 3.72 | 0.0 | 0.715 | 0.581 | 0.881 | ||
| AG+AA vs GG | 0.95 (0.84–1.09) | 0.70 | 0.487 | 6.14 | 2.2 | 0.408 | 0.093 | 0.652 | ||
| AA vs AG+GG | 1.10 (0.94–1.30) | 1.17 | 0.241 | 2.34 | 0.0 | 0.886 | 0.824 | 0.762 | ||
| A vs G | 1.01 (0.92–1.10) | 0.16 | 0.873 | 4.37 | 0.0 | 0.627 | 0.172 | 0.230 | ||
Bold values denote statistical significance at the P <0.05 level.