Table 1.
Selectivity indices assay of 10 candidate hits.
| TCMs and positive control | Botanical extracts | IC50 (μg/mL)a | CC50 (μg/mL)b | SIc |
|---|---|---|---|---|
| Areca catechu L. | n-Butanol fraction | 1.08 | 50.73 | 46.97 |
| Areca catechu L. | Water fraction | 1.27 | 101.2 | 79.69 |
| Glycyrrhizin | Cyclohexane fraction | 2.12 | 21.27 | 10.03 |
| Glycyrrhizin | Ethyl acetate fraction | 6.45 | 48.5 | 7.52 |
| Cinnamon | n-Butanol fraction | 1.94 | 190.9 | 98.40 |
| Cinnamon | Water fraction | 1.95 | 127.8 | 65.54 |
| Tripterygium wilfordii | n-Butanol fraction | 1.81 | 74.43 | 41.12 |
| Spatholobus suberectus | n-Butanol fraction | 1.99 | 102.3 | 51.41 |
| Polygonum cuspidatum | n-Butanol fraction | 1.56 | 136.2 | 87.31 |
| Magnolia officinalis | Ethyl acetate fraction | 3.55 | 42.94 | 12.10 |
| BXA | — | 0.0015 | >0.097 | >65 |
a: IC50, 50% inhibitory concentration; b: CC50, 50% cytotoxicity concentration; c: SI, selectivity index, SI= CC50/IC50. Baloxavir acid as the positive control. The inhibitory and cytotoxicity effects were analyzed using GraphPad Prism 5.