Figure 1. Participant Flow in the RICH Trial.

Abbreviations: ICU, intensive care unit; RICH, Regional Citrate vs Systemic Heparin Anticoagulation for Continuous Kidney Replacement Therapy in Critically Ill Patients with Acute Kidney Injury.

^aSevere sepsis or septic shock, use of vasopressor, refractory fluid overload.

^bRandomization was performed centrally in a 1:1 proportion using the Pocock minimization method of stratified randomization, accounting for the factors study center, sex, cardiovascular Sequential Organ Failure Assessment (SOFA) score (0-2 vs 3-4), and presence or absence of oliguria.^9,14

^cReasons for including but not analyzing patients were refusal of the guardianship procedure by the local court, no written consent of guardian prior to the death of the patient, no written consent of the guardian at all, or timeline issues (details reported in Supplement 3)