Table 2.

In vitro studies of a combination of serratiopeptidase and antibiotics for biofilm treatment.

Serratiopeptidase combinations with the antibiotics	Biofilms	Results	Reference
Ofloxacin	Staphylococcus epidermidis Pseudomonas aeruginosa	-Serratiopeptidase enhanced the activity of ofloxacin and inhibited biofilm formation	Selan et al. [29]
Azithromycin	Bacterial biofilms growing on vascular graft surface	- Combination of serratiopeptidase and azithromycin was found to be very effective against Stayphalococcus strains by showing less minimum inhibitory concentration (MIC) compared to other antibiotic treatments	Thaller et al. [30]
Ciprofloxacin	Staphylococcus aureus	- Combination of serratiopeptidase (50 μg/mL) and ciprofloxacin at sub-MIC concentration cleared biofilm on catheter.	Gupta and Nagarsenke (2015)
Vancomycin and rifampicin	Methicillin resistant and methicillin susceptible strains of S. aureus	- Effective in dispersing biofilm independent of the strain of organism.	Hogan et al. [31]
Levofloxacin	Staphylococcus aureus	- Eradicated >90 % of the preformed biofilm - Combination showed synergistic activity	Gupta et al. [32]