Fig. 3.

Graphical representation of the five candidate pathways and their significantly contributing genes. Network-based representation of the five candidate pathways. Selected genes shown (brown nodes) correspond to genes that contribute to significant enrichment of each pathway in the patient single-sample signatures. Node sizes represent number of times each gene appears in the leading edge in the single-sample pathway enrichment analysis (i.e., indicating significant changes in activity of this pathway across Training cohort).