Fig. 7.

Risk scores of tamoxifen resistance identity patients with significant difference in treatment-related survival. (a) Schematic representation of the risk score to fail tamoxifen (i.e., treatment failure score). Top: read-out genes for candidate molecular pathways are assigned; Middle: expression values for the read-out genes are multiplied by their corresponding weights (i.e., ROC values); Bottom: the weighted expression values are then summed and utilized to assign low/intermediate or high risk of failing tamoxifen. (b-e) Validation studies using risk scores in Test cohort 1 (b, c) and Test cohort 2 (d, e). (b) Distribution of risk scores in Test cohort 1, with low/intermediate and high risk patients indicated. (c) Kaplan-Meier survival analysis, comparing low-intermediate and high risk patient groups in Test cohort 1. (d) Distribution of risk scores in Test cohort 2, with low/intermediate and high risk patients indicated. (e) Kaplan-Meier survival analysis, comparing low-intermediate and high risk patient groups in Test cohort 2.