Table 3.

The most significant 20 Functional Connectivity Links associated with Hypertension history from the UK Biobank analysis using 15,086 participants. A t-test was performed for different functional connectivities between the group categorized as having a history of hypertension (n = 2720) and the participants without a history of hypertension (n = 12,366). The significance value for the links is p<0.005 corrected by the FDR method. Each link is between two areas defined in the AAL2 atlas. A link negatively correlated with hypertension indicates that the functional connectivity of that link is lower in the hypertension group than the control group. The brain area names used are those for the corresponding AAL2 area shown in Table S1.

Functional Connectivity		t value	Cohens's d	p value
Temporal_Pole_Sup_L	Temporal_Pole_Mid_L	−6.94	−0.113	4.20E-12
Hippocampus_L	Hippocampus_R	−6.82	−0.111	9.72E-12
Fusiform_L	Fusiform_R	−6.56	−0.107	5.39E-11
Hippocampus_R	Temporal_Pole_Sup_L	−6.49	−0.106	8.62E-11
Occipital_Inf_L	Occipital_Inf_R	−6.27	−0.102	3.65E-10
Lingual_L	Lingual_R	−6.21	−0.101	5.57E-10
Hippocampus_R	Temporal_Inf_R	−6.19	−0.101	6.12E-10
Hippocampus_R	Temporal_Pole_Sup_R	−6.17	−0.100	7.04E-10
Hippocampus_R	Occipital_Inf_L	−6.11	−0.099	1.03E-09
Hippocampus_R	Temporal_Mid_L	−5.99	−0.098	2.16E-09
Hippocampus_R	Heschl_R	−5.96	−0.097	2.56E-09
Hippocampus_R	Temporal_Inf_L	−5.92	−0.096	3.31E-09
Temporal_Pole_Sup_L	Temporal_Mid_L	−5.92	−0.096	3.39E-09
Hippocampus_R	Occipital_Inf_R	−5.89	−0.096	3.89E-09
Temporal_Pole_Sup_L	Temporal_Pole_Mid_R	−5.86	−0.095	4.73E-09
Hippocampus_R	Paracentral_Lobule_L	−5.83	−0.095	5.57E-09
Insula_R	SupraMarginal_R	−5.82	−0.095	6.06E-09
Thalamus_L	Thalamus_R	−5.82	−0.095	6.17E-09
Hippocampus_L	Temporal_Pole_Sup_L	−5.77	−0.094	8.30E-09
Frontal_Sup_2_L	Hippocampus_R	−5.74	−0.093	9.67E-09