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. 2020 Oct 19;12:759–766. doi: 10.2147/NSS.S270045

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© 2020 wang et al.

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Activation of peripheral NLRP3 inflammasome in insomnia patients with objective short sleep duration. (A and B) Relative expression levels (A) and Western blot bands (B) of peripheral NLRP3, ASC, and caspase l, normalized to the values of GAPDH in IOSSD, IONSD, and healthy controls. (C and D) Serum levels of IL-lβ (C) and IL-18 (D) determined by ELISA. Results are presented as mean ± standard deviation. One-way ANOVA *P < 0.05 versus healthy controls; ^#P < 0.05 versus IONSD.

Abbreviations: IOSSD, insomnia with objective short sleep duration; IONSD, insomnia with objective normal sleep duration; CON, healthy controls; NLRP3, NOD-like receptor protein 3; ASC, apoptosis-associated speck-like protein; GAPDH, glyceraldehyde phosphate dehydrogenase; IL-1β, interleukin-1β; IL-18, interleukin-18.