Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
IC50 Values of AsnEDAs Against P. falciparum Proteasoe, Human β5i and β5c
| Compound | IC50 (nM) | EC50 (nM) | |||
|---|---|---|---|---|---|
| β5i | β5c | Pf20S β5 | Pf 3D7 | HepG2 | |
| PKS21004 | 58 | 326 | 3.6 | 4.6 | 3,670 |
| 4 | 2090±29 | ˃100,000 | 2576±326 | ˃2770 | ˃11,000 |
| 5 | 2892±1004 | ˃100,000 | 15,135±4565 | ˃2770 | ˃11,000 |
| 6 | 112±11 | 430±130 | 4.7±1.4 | 3.1±0.1 | ˃11,000 |
Abbreviation: Pf 3D7, P. falciparum heparin binding protein 3D7.
