Table 1.
The Clinicopathological Characteristics of MSI-Negative and MSI-Positive Cancers
| Characteristics | No. of Patients (%) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Endometrial Cancers (n=150) | Colorectal Cancers (n=150) | Liver Cancers (n=150) | Gastric Cancers(n=150) | ||||||||||
| All (n=600) | MSI-Negative (n=124) | MSI-Positive (n=26) | p | MSI-Negative (n=135) | MSI-Positive (n=15) | p | MSI-Negative (n=146) | MSI-Positive (n=4) | p | MSI-Negative (n=146) | MSI-Positive (n=4) | p | |
| Age, yr | 0.495 | 0.736 | 0.467 | 0.062 | |||||||||
| Median | 56.5±10.9 | 55.3±9.5 | 54.2±8.8 | 59.5±12.2 | 55.4±16.9 | 54.3±9.0 | 49.3±7.1 | 57.5±11.7 | 65.0±2.9 | ||||
| <65 | 455 (75.8) | 103 (83.1) | 23 (88.5) | 84 (62.2) | 10 (66.7) | 129 (88.4) | 4 (100.0) | 101 (69.2) | 1 (25.0) | ||||
| ≥65 | 145 (24.2) | 21 (16.9) | 3 (11.5) | 51 (37.8) | 5 (33.3) | 17 (11.6) | 0 (0.0) | 45 (30.8) | 3 (75.0) | ||||
| Gender | / | 0.252 | 0.376 | 0.415 | |||||||||
| Male | 308 (51.3) | / | / | 69 (51.1) | 10 (66.7) | 122 (83.6) | 4 (100.0) | 101 (69.2) | 2 (50.0) | ||||
| Female | 292 (48.7) | 124 (100.0) | 26 (100.0) | 66 (48.9) | 5 (33.3) | 24 (16.4) | 0 (0.0) | 45 (30.8) | 2 (50.0) | ||||
| Location | <0.001 | ||||||||||||
| Colon | / | / | / | 13 (9.6) | 7 (46.7) | / | / | / | / | ||||
| Left | / | / | / | 4 (3.0) | 2 (13.3) | / | / | / | / | ||||
| Right | / | / | / | 21 (15.6) | 5 (33.3) | / | / | / | / | ||||
| RS junction | / | / | / | 10 (7.4) | 0 (0.0) | / | / | / | / | ||||
| Rectum | / | / | / | 87 (64.4) | 1 (6.7) | / | / | / | / | ||||
| Clinical stage | 0.559 | 0.354 | 0.601 | 0.038 | |||||||||
| I/II | 332 (55.3) | 110 (88.7) | 23 (88.5) | 68 (50.4) | 10 (66.7) | 76 (52.1) | 1 (25.0) | 41 (28.1) | 3 (75.0) | ||||
| III/IV | 268 (44.7) | 14 (11.3) | 3 (11.5) | 67 (49.6) | 5 (33.3) | 70 (47.9) | 3 (75.0) | 105 (71.9) | 1 (25.0) | ||||
| Histological type | 0.012 | 0.705 | |||||||||||
| Mucinous | / | / | / | 25 (18.5) | 7 (46.7) | / | / | 5 (3.5) | 0 (0.0) | ||||
| Nonmucinous | / | / | / | 110(81.5) | 8 (53.3) | / | / | 139 (96.5) | 4 (100.0) | ||||
| IHC for MMR protein | |||||||||||||
| Loss of MLH1 | / | / | / | 0 (0.0) | 5 (33.3) | <0.001 | / | / | / | / | |||
| Loss of MSH2 | / | / | / | 0 (0.0) | 3 (20.0) | <0.001 | / | / | / | / | |||
| Loss of MSH6 | / | / | / | 1 (0.7) | 4 (26.7) | <0.001 | / | / | / | / | |||
| Loss of PMS2 | / | / | / | 1 (0.7) | 6 (40.0) | <0.001 | / | / | / | / | |||
Abbreviations: IHC, immunohistochemistry; MMR, mismatch repair; MSI, microsatellite instability.