Fig. 2. The ALS/FTLD causative genes co-aggregated with TDP-43 induce cytoplasmic translocation of wild-type TDP-43.
A Representative images of the screening results with N2a cells stably expressing EGFP-fused wild-type TDP-43 (TDP-43WT). Arrowheads indicate cytoplasmic co-aggregates of the Group 1 gene products and TDP-43WT. Scale bars = 20 µm. B The summary of the TDP-43 co-aggregation screening. The genes in Group 1 were further classified into two subgroups based on their physiological functions: microtubule-related proteins (MRPs) and RNA-binding proteins (RBPs).