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. 2020 Oct 19;15:7979–7993. doi: 10.2147/IJN.S275650

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© 2020 Wu et al.

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In vitro assay of cells treated with PBS, BMSC-Exos or mag-BMSC-Exos. (*) p < 0.05, (**) p < 0.01, (***) p < 0.001. (A) Representative images showing the migration ability of HUVECs at 24 h by scratch wound assay; the yellow dashed lines are the edges of the cell migration. Scale bar = 200 μm. (B) Quantitative analysis of the wound size recovery rate of HUVECs. (C) Representative images showing migrated HUVECs using the transwell assay. Scale bar = 200 μm. (D) Quantitative analysis of the migration rate of HUVECs. (E) Representative images showing tube formation in HUVECs. Scale bar = 200 μm. (F) Quantitative analysis of the tube formation assay. The values of the average tube length were measured. (G) Representative images showing migrated HSFs using the transwell assay. Scale bar = 200 μm. (H) Quantitative analysis of the migration rate of HSFs. (I and J) qRT-PCR analysis of the angiogenesis-related genes VEGF (I) and HIF-1α (J) at days 4 and 7. (K and L) qRT-PCR analysis of the fibrogenesis-related genes PDGFRα (K) and bFGF (L) at days 2 and 4. (M) Western blotting assay for the protein expression of VEGF, HIF-1α, PDGFRα and bFGF.