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. 2020 Oct 19;15:7979–7993. doi: 10.2147/IJN.S275650

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© 2020 Wu et al.

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Exosomal miR-21-5p promotes angiogenesis and fibrogenesis by targeting SPRY2 in vitro. (*) p < 0.05, (**) p < 0.01, (***) p < 0.001. (A) Overexpression of SPRY2 prevented the upregulation of the migration rate of HUVECs induced by the miR-21-5p mimic. Scale bar = 200 μm. (B) Quantitative analysis of the migration rate of HUVECs. (C) Overexpression of SPRY2 prevented the upregulation of the migration rate of HSFs induced by the miR-21-5p mimic. Scale bar = 200 μm. (D) Quantitative analysis of the migration rate of HSFs. (E) Western blotting assays showed that overexpression of SPRY2 prevented the upregulation of AKT, p-AKT, ERK1/2 and p-ERK1/2 protein expression induced by the miR-21-5p mimic. (F) Schematic model showing that magnetic exosomal miR-21-5p targeted SPRY2 and activated the PI3K/AKT and ERK1/2 signaling pathways, further promoting angiogenesis and fibrogenesis.