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. 2020 Oct 19;13:10607–10619. doi: 10.2147/OTT.S257747

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© 2020 Lu et al.

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Silencing APE1 remarkably suppressed the proliferation, invasion and radioresistance of GC cells. (A) APE1 overexpression plasmid and si-APE1 were transfected into AGS cells and BGC-823 cells, respectively, and then qRT-PCR was performed to detect the expression of APE1. (B) The proliferation of GC cells was detected by CCK-8 method. (C) Flow cytometry was used to detect apoptosis of GC cells. (D) Transwell method was used to detect the migration and invasion of GC cells. (E) The effect of APE1 on radiation resistance of GC cells was examined by colony formation assay. *, ** and *** represent P < 0.05, P < 0.01 and P < 0.001, respectively.