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. 2020 Oct 24;11(10):912. doi: 10.1038/s41419-020-03121-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The expression of miR-488 was significantly decreased in all examined breast cancer cell lines, especially in triple-negative breast cancer (TNBC) cells. B The suppression of endogenous miR-488 in MCF-7 cells significantly changed their morphology with obvious pseudopodia stretching out (red arrows). C The increased expression of miR-488 was conducted through transfecting miR-488 mimic. D The proliferation rate of MDA-MB-231 cells was significantly suppressed with exogenous miR-488 by a miR-488 mimic. E The number of cell colonies was decreased in MDA-MB-231 cells treated by a miR-488 mimic. F The decreased expression of miR-488 was performed through transfecting miR-488 inhibitors. G The proliferation rate of MCF-7 cells was promoted by miR-488 inhibitors to suppressing the endogenous miR-488. H The number of MCF-7 cell colonies was formed more in the miR-488 inhibitor-treated group than that in negative control (NC) cells. *p < 0.05, **p < 0.01, and ***p < 0.001.