Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Safety issues in gene therapy products using genome-editing techniques
| • Off-target effects |
| • On-target mutagenesis |
| • Chromosomal changes (translocation/inversion/deletion) |
| • P53 mutation |
| • Immunogenicity of nucleases |
| • Germline modification |
