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. 2020 Oct 16;31(19-20):1114–1123. doi: 10.1089/hum.2020.099

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Copyright 2020, by Mary Ann Liebert, Inc., publishers

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Figure 5. — Transduction efficiency of ssAAV8-FIX and scAAV3-FIX vectors in hemophilia B mice. (a) Four hemophilia B mice per group were injected with 1 × 10¹⁰ vgs of ssAAV8-hAAT-FIX, or scAAV8-HSh-TTR-Padua-FIX-LCO vectors via the tail-vein, and serum FIX levels were determined by ELISA 3 weeks postvector administration. Hemophilia B mice (n = 3 per group) were injected with 1 × 10⁹ or 1 × 10¹⁰ vgs/mouse of scAAV8-HSh-TTR-Padua-FIX-LCO vectors via the tail-vein, and (b) FIX levels and (c) two-stage FIX activity were determined at 2 and 8 weeks postvector administration.