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. 2020 Oct 20;13:3821–3830. doi: 10.2147/DMSO.S276184

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© 2020 Xue et al.

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MG IIIE alleviated inflammation and oxidative stress of HG-induced podocytes. The contents of inflammatory factors including (A) TNF-α, (B) IL-1β and (C) IL-6 were examined using ELISA kits, respectively. The level of (D) MDA and the activities of (E) SOD and (F) CAT were assessed using commercially available kits, respectively. (G) Western blot analysis was employed to measure the expression of MCP-1, NLRP3, ASC and caspase1 proteins. ***P<0.001 vs. MA; ^##P<0.01, ^###P<0.001 vs. HG.

Abbreviations: MG IIIE, Mogroside IIIE; NG, normal glucose; HG, high glucose; MA, mannitol; TNF-α, tumor necrosis factor-α; IL, interleukin; ELISA, enzyme-linked immunosorbent assay; MDA, malondialdehyde; SOD, superoxide dismutase; CAT, catalase.