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. 2020 Oct 20;13:3821–3830. doi: 10.2147/DMSO.S276184

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© 2020 Xue et al.

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MG IIIE mitigated inflammation and oxidative stress by activating AMPK/SIRT1 signaling pathway in HG-induced podocytes. The levels of (A) TNF-α, (B) IL-1β and (C) IL-6 were determined using ELISA kits, respectively. The content of (D) MDA and the activities of (E) SOD and (F) CAT were evaluated using commercially available kits, respectively. (G) The expression of MCP-1, NLRP3, ASC and caspase1 proteins was examined by Western blot analysis. ***P<0.001 vs. HG; ^#P<0.05, ^##P<0.01, ^###P<0.001 vs. HG+ MG IIIE.

Abbreviations: MG IIIE, Mogroside IIIE; HG, high glucose; TNF-α, tumor necrosis factor-α; IL, interleukin; ELISA, enzyme-linked immunosorbent assay; MDA, malondialdehyde; SOD, superoxide dismutase; CAT, catalase.