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. 2020 Oct 20;12:10397–10409. doi: 10.2147/CMAR.S244374

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© 2020 Wu et al.

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The GSDMD expression is reduced in human colorectal cancer tissues and is significantly related to the overall survival of CRC patients. (A and B) The protein levels of GSDMD in CRC patients and the tissue samples of the corresponding non-malignant adjacent were measured by Western blot analysis (n=40). (C) Immunohistochemical analysis of GSDMD expression in human colorectal cancer tissues (n=244). (D) The Kaplan–Meier method was performed to compare the overall survival (OS) in 244 patients with CRC with the low and high GSDMD protein expression level groups. (E and F) Using Western blot analysis to assess the GSDMD and GSDMD-N expression in colorectal cancer tissue culture with LPS (10μg/mL) or normal saline for 24 h (n=6). Data are shown as the mean ± SD. *P<0.05, ***P<0.001 compared with the control group.