Table 4.
Univariate Analysis and Multiple Regression Analysis Showing the Predictive Power of Both Biomarkers for Diagnosing NAFLD and Its Grades According to NAS Score
| Univariate Analysis* | OR | 95% CI | p-value | ||
|---|---|---|---|---|---|
| LPS | 1.35 | 1.152–1.576 | 0.001** | ||
| CD163 | 1.99 | 1.455–2.746 | 0.001** | ||
| Multiple Regression Analysis** | |||||
| NAS | AOR | 95% CI | p-value | ||
| LPS | Not NASH | 1 (Reference) | |||
| Borderline NASH | 1.377 | 0.965–1.966 | 0.07 | ||
| NASH | 1.453 | 1.015–2.078 | 0.04 | ||
| CD163 | Not NASH | 1 (Reference) | |||
| Borderline NASH | 1.896 | 1.144–3.142 | 0.01 | ||
| NASH | 2.160 | 1.283–3.637 | 0.004 | ||
Notes: *Univariate analysis showing the predictive power of LPS (lipopolysaccharide) and CD163 for NAFLD (Non-alcoholic fatty liver disease). **Multiple regression analysis showing the predictive power of both biomarkers for the diagnosis of NASH and Borderline NASH versus Not-NASH with adjusted OR. p-value calculated depend on logistic regression analysis.
Abbreviations: AOR, adjusted odd ratio; C.I, confidence interval; CD163, cluster of differentiation 163; LPS, lipopolysaccharide; NASH, non-alcoholic steatohepatitis; NAFLD, non-alcoholic fatty liver disease; OR, odds ratio.