Table 2.

Comparison Between Study Group Before and After the Injection of STZ/Nicotinamide According to Biochemical Parameters

	Study Group		p-value
	Before (n=17)	After (n=17)
Urine creatinine (mg/kg/24 h).			0.076
Mean SD	24.7±10.5	13.3±10.0
Median (Range)	22.5 (10–50)	10 (5–40)
24-h protein (mg/24 hour).			0.001
Mean SD	23.8±15.4	52.8±16.7
Median (range)	11 (9–46)	23 (2–60)
A:C ratio (mg albumin:g creatinine)			0.001
Mean SD	1.13 ± 0.2	6.4 ± 1.1
Median (range)	1 (0.2–6.5)	2 (0.2–4.5)
Serum creatinine (mg/dL)			0.032
Mean SD	0.6±0.1	0.7±0.2
Median (range)	0.6 (0.5–0.7)	0.7 (0.5–1)
Serum urea (mg/dL)			0.148
Mean SD	39.5±11.7	55.2±23.0
Median (range)	42 (15–60)	53 (19–125)
24-h urinary CyPA (ng/mL).			>0.001
Mean SD	1.1±0.3	2.1±0.6
Median (range)	1 (0.7–1.7)	2 (1.3–3.2)
Blood glucose (mg/dL)			>0.001
Mean SD	137.4±19.7	469.5±102.3
Median (range)	135 (99–170)	431 (290–600)
Urine volume (mL/24 h)			<0.001
Mean SD	6.1±2.2	45.6±11.2
Median (range)	5.8 (3–10)	46.5 (25–66)
Weight (g)			<0.001
Mean SD	290.3±41.3	170.5±16.7
Median (range)	285 (240–410)	170 (140–200)

Note: Data are presented as mean ±SD and median (range).

Abbreviations: STZ, streptozotocin; CyPA, cyclophilin A.